Do you find our website to be helpful?
Yes   No

Use of PGD to Avoid Affected Children in Couples Carrying Dominant Genetic Traits for Disease

Preimplantation genetic diagnosis (PGD) is beneficial to couples who carry dominant genetic traits and wish to avoid having affected children.



Family health history plays an important role in the health of a child. An individual has two copies of nearly every gene, one from each parent. Changes, or mutations, in a gene, interferes with the way it works and can cause disease.

Dominant genetic mutations are mutations that are present in only one copy of that particular gene. That means a parent that has a dominant mutated gene can pass the trait on to a child. If one parent has an autosomal dominant disorder, each child they conceive will have a 50 percent chance of inheriting that disease. Spontaneous mutations can also occur in individuals with no family history of the disease.

Autosomes are non-sex determining genes. Examples of autosomal dominant diseases include Huntington’s disease, neurofibromatosis, achondroplasia and familial hypercholesterolemia.

X-linked dominant diseases occur as a result of mutated genes located on the X chromosome. Males have only one X chromosome, so both dominant and recessive mutated genes on the X- chromosome will cause disease in males. Often, both males and females in each generation will be affected in families that have X-linked dominant disorders.



There are numerous genetic traits that can be identified through PGD. Some examples of dominant genetic disorders include Huntington’s disease, Marfan’s syndrome, achondroplasia (a type of dwarfism), some types of glaucoma, and polydactyly (extra fingers or toes).



Individuals who have, or who are a risk for having, a specific disease that could be passed on to their child are advised to consider PGD. Preimplantation genetic diagnosis may be beneficial for couples undergoing IVF, increasing the chances that only healthy embryos are transferred.



Embryo biopsy is typically performed on day five and six. Testing is safe and does not cause harm to the embryo.

A few cells are removed and tested for genetic abnormalities. The results are used to determine which embryo(s) are appropriate for transfer. Typically, embryos with normal test results and morphology are eligible for transfer.

You Might Also Enjoy...

Fertility Treatments for Gay and Lesbian Couples

With today’s reproductive technology, same-sex couples have options to achieve their dream of building their family. At University Reproductive Associates, we are proud to support all paths to parenthood and help you build a happy, healthy family.

Why is Facial Hair Growth a Symptom of PCOS?

If you have polycystic ovary syndrome (PCOS), you know it affects your periods and your fertility. But many people don’t know that it can cause facial hair growth as well. Read on to learn more about PCOS.

Managing Food While Pregnant

Now that you’re finally pregnant, you want to do everything you can to ensure optimal fetal development, a smooth delivery, and a healthy baby — and that means nutrition. Here’s what you need to know about what to eat when you’re expecting.

The Link Between Diabetes and Miscarriage

Pregnancy should be a joyful time of reflection and anticipation. But if you have diabetes, you may be concerned about how it will affect your baby. And rightly so, as it’s linked to miscarriage. Here’s what you need to know.

How Uterine Septum Can Cause Infertility

Miscarriages and infertility can be heartbreaking, but if your reproductive challenges are due to a uterine septum, there’s hope for successful treatment, full-term pregnancy, and babies. Read on to learn more.